Low-and high-level coordination of orofacial motor actions

D Kleinfeld, M Deschênes, MN Economo… - Current opinion in …, 2023 - Elsevier
Orofacial motor actions are movements that, in rodents, involve whisking of the vibrissa,
deflection of the nose, licking and lap** with the tongue, and consumption through …

The whisking oscillator circuit

J Takatoh, V Prevosto, PM Thompson, J Lu, L Chung… - Nature, 2022 - nature.com
Central oscillators are primordial neural circuits that generate and control rhythmic
movements,. Mechanistic understanding of these circuits requires genetic identification of …

A change in behavioral state switches the pattern of motor output that underlies rhythmic head and orofacial movements

SM Liao, D Kleinfeld - Current Biology, 2023 - cell.com
The breathing rhythm serves as a reference that paces orofacial motor actions and
orchestrates active sensing. Past work has reported that pacing occurs solely at a fixed …

Cerebellar state estimation enables resilient coupling across behavioural domains

ER Palacios, P Chadderton, K Friston, C Houghton - Scientific Reports, 2024 - nature.com
Cerebellar computations are necessary for fine behavioural control and may rely on internal
models for estimation of behaviourally relevant states. Here, we propose that the central …

Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

MR Melo, AD Wykes, AA Connelly, JK Bassi… - Elife, 2023 - elifesciences.org
The pre-Bötzinger complex (preBötC), a key primary generator of the inspiratory breathing
rhythm, contains neurons that project directly to facial nucleus (7n) motoneurons to …

A brainstem circuit for the expression of defensive facial reactions in rat

AC Pérez, M Demers, A Fassihi, JD Moore, D Kleinfeld… - Current Biology, 2023 - cell.com
The brainstem houses neuronal circuits that control homeostasis of vital functions. These
include the depth and rate of breathing 1, 2 and, critically, apnea, a transient cessation of …

California mice (Peromyscus californicus) adjust mouth movements for vocal production during early postnatal development

K Preston, T Riede - BMC biology, 2024 - Springer
Abstract Background The order Rodentia is the largest group of mammals. Diversification of
vocal communication has contributed to rodent radiation and allowed them to occupy …

Elephant trunks: Strength and dexterity from mini-fascicles

W Olson, L Zhang, DH O'Connor, D Kleinfeld - Current Biology, 2023 - cell.com
Muscular hydrostats, such as the elephant trunk, can perform precise motor actions. A new
study has revealed that the elephant trunk contains a dense network of tiny muscle fascicles …

The spinal premotor network driving scratching flexor and extensor alternation

M Yao, A Nagamori, E Azim, T Sharpee, M Goulding… - bioRxiv, 2025 - biorxiv.org
Rhythmic motor behaviors are generated by neural networks termed central pattern
generators (CPGs). Although locomotor CPGs have been extensively characterized, it …

A toolbox for ablating excitatory and inhibitory synapses

A Bareghamyan, C Deng, S Daoudi, S Nawy, X Lu… - bioRxiv, 2024 - biorxiv.org
Recombinant optogenetic and chemogenetic proteins that manipulate neuronal activity are
potent tools for activating and inhibiting neuronal circuit function. However, there are few …