Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

Fibrinolysis is a series of enzymatic reactions that degrade insoluble fibrin. Plasminogen
activators convert the zymogen plasminogen to the active serine protease plasmin, which …

Apolipoprotein B (apoB)–lipoproteins initiate and promote atherosclerotic cardiovascular
disease. Plasma tissue plasminogen activator (tPA) activity is negatively associated with …

Interactions between vascular smooth muscle cells (VSMCs), endothelial cells (ECs),
pericytes (PCs) and macrophages (MФ), the major components of blood vessels, play a …

Context It is unclear to what extent the plasma proteome of abdominal fat distribution differs
from that of body mass index, and whether the differences have clinical implications …

Low fibrinolytic activity has been associated with pathologic thrombosis and multiple-organ
failure. Low fibrinolytic activity has two commonly associated terms, hypofibrinolysis and …

Background Patients with COVID-19 have a higher risk of thrombosis and
thromboembolism, but the underlying mechanism (s) remain to be fully elucidated. In …

Exercise testing unmasks more exaggerated systolic blood pressure responses (SBP) in
Black compared with White male adults. Such responses, if translatable to females, may …

The superfamily of serine protease inhibitors (SERPINs) are a class of inhibitors that utilise a
dynamic conformational change to trap and inhibit their target enzymes. Their powerful …

Diabetic retinopathy (DR) is one of the most common and serious microvascular
complications of diabetes mellitus, the incidence of which has been increasing annually …