Recent advances in our understanding of the environmental, epidemiological, immunological, and clinical dimensions of coccidioidomycosis
Coccidioidomycosis is the endemic mycosis caused by the fungal pathogens Coccidioides
immitis and C. posadasii. This review is a summary of the recent advances that have been …
immitis and C. posadasii. This review is a summary of the recent advances that have been …
Utility of voriconazole therapeutic drug monitoring: a meta-analysis
Background Voriconazole therapeutic drug monitoring (TDM) is increasingly used in clinical
practice. However, the utility of voriconazole TDM to guide therapy remains uncertain and …
practice. However, the utility of voriconazole TDM to guide therapy remains uncertain and …
Therapeutic drug monitoring of systemic antifungal agents: a pragmatic approach for adult and pediatric patients
J John, A Loo, S Mazur, TJ Walsh - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Therapeutic drug monitoring (TDM) has been shown to optimize the
management of invasive fungal infections (IFIs), particularly for select antifungal agents with …
management of invasive fungal infections (IFIs), particularly for select antifungal agents with …
UPLC-MS/MS method for the simultaneous determination of imatinib, voriconazole and their metabolites concentrations in rat plasma
R Xu, Q Lin, X Qiu, J Chen, Y Shao, G Hu… - Journal of Pharmaceutical …, 2019 - Elsevier
In the present study, a simple ultra-performance liquid chromatography tandem mass
spectrometry (UPLC-MS/MS) method used to measure the plasma concentrations of …
spectrometry (UPLC-MS/MS) method used to measure the plasma concentrations of …
Voriconazole pharmacokinetics and exposure–response relationships: assessing the links between exposure, efficacy and toxicity
The triazole antifungal voriconazole (VCZ) exhibits broad-spectrum antifungal activity and is
the first-line treatment for invasive aspergillosis. Highly variable, non-linear …
the first-line treatment for invasive aspergillosis. Highly variable, non-linear …
Achieving target voriconazole concentrations more accurately in children and adolescents
Despite the documented benefit of voriconazole therapeutic drug monitoring, nonlinear
pharmacokinetics make the timing of steady-state trough sampling and appropriate dose …
pharmacokinetics make the timing of steady-state trough sampling and appropriate dose …
Therapeutic drug monitoring of antifungal drugs: another tool to improve patient outcome?
Introduction This study aimed to examine the relationship among adequate dose, serum
concentration and clinical outcome in a non-selected group of hospitalized patients …
concentration and clinical outcome in a non-selected group of hospitalized patients …
Recent advances in therapeutic drug monitoring of voriconazole, mycophenolic acid, and vancomycin: a literature review of pediatric studies
M Resztak, J Sobiak, A Czyrski - Pharmaceutics, 2021 - mdpi.com
The review includes studies dated 2011–2021 presenting the newest information on
voriconazole (VCZ), mycophenolic acid (MPA), and vancomycin (VAN) therapeutic drug …
voriconazole (VCZ), mycophenolic acid (MPA), and vancomycin (VAN) therapeutic drug …
Effect of therapeutic drug monitoring and cytochrome P450 2C19 genoty** on clinical outcomes of voriconazole: a systematic review
Objectives To examine current knowledge on the clinical utility of therapeutic drug
monitoring (TDM) in voriconazole therapy, the impact of CYP2C19 genotype on …
monitoring (TDM) in voriconazole therapy, the impact of CYP2C19 genotype on …
Challenges in the treatment of invasive aspergillosis in immunocompromised children
Invasive aspergillosis (IA) is associated with significant morbidity and mortality. Voriconazole
remains the drug of choice for the treatment of IA in children; however, the complex kinetics …
remains the drug of choice for the treatment of IA in children; however, the complex kinetics …