Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …

Abstract Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …

Recent experimental evidence suggests that transcellular propagation of fibrillar protein
aggregates drives the progression of neurodegenerative diseases in a prion-like manner …

The ability to express or deplete proteins in living cells is crucial for the study of biological
processes. Viral vectors are often useful to deliver DNA constructs to cells that are difficult to …

The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …

Nucleic acids and their synthetic oligonucleotide (ON) analogs are a group of gene
therapeutic compounds which hold enormous clinical potential. Despite their undoubted …

Peptides are emerging as attractive drug delivery tools. The HIV Tat-derived peptide is a
small basic peptide that has been successfully shown to deliver a large variety of cargoes …

HIV‐1 encodes for the small basic protein Tat (86–101 residues) that drastically enhances
the efficiency of viral transcription. The mechanism enabling Tat nuclear import is not yet …

Arginine-rich peptides, including octaarginine (R8), HIV-1 Tat, and branched-chain arginine-
rich peptides, belong to one of the major classes of cell-permeable peptides which deliver …

Mesoporous silica nanoparticles functionalized with peptides are developed for sequential
drug delivery. The RGD peptide is used for vasculature/cell membrane targeting and the …