Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Designing new medicines more cheaply and quickly is tightly linked to the quest of exploring
chemical space more widely and efficiently. Chemical space is monumentally large, but …

Computer-aided synthesis planning (CASP) tools can propose retrosynthetic pathways and
forward reaction conditions for the synthesis of organic compounds, but the limited …

The molecules of today—the medicines that cure diseases, the agrochemicals that protect
our crops, the materials that make life convenient—are becoming increasingly sophisticated …

Synthetic chemistry provides access to advanced materials that facilitate innovation in key
industries such as medicine, energy, and agriculture. Automation is poised to challenge the …

How do you get into flow? We trained in flow chemistry during postdoctoral research and are
now applying it in new areas: materials chemistry, crystallization, and supramolecular …

Natural product synthesis has lain at the heart of organic chemistry. Complex structures of
natural products have inspired chemists to develop new methods and strategies. The utility …

Recent literature suggests that the fields of machine learning (ML) and high-throughput
experimentation (HTE) have separately received considerable attention from chemists and …

The concept and practices of chemical synthesis are being profoundly transformed toward
the development of fully autonomous continuous processes. Critical to the development of …

Achieving autonomous multi-step synthesis of novel molecular structures in chemical
discovery processes is a goal shared by many researchers. In this Comment, we discuss key …