There must be something unique about a class of drugs (discovered and developed in the
mid-1940s) where there are more than 130 ongoing clinical trials currently listed …

Prion diseases share common clinical and pathological characteristics such as spongiform
neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed …

Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …

Summary Background Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion
encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Transmissible spongiform encephalopathies (TSEs) are fatal, untreatable
neurodegenerative diseases associated with the accumulation of a disease-specific form of …

Tetracyclines were developed as a result of the screening of soil samples for antibiotics. The
firstt of these compounds, chlortetracycline, was introduced in 1947. Tetracyclines were …

Secondary metabolites have been found to have interesting applications over and above
their well-known medical uses, eg, as antimicrobials, etc. These alternative applications …

Based on in vitro observations in scrapie-infected neuroblastoma cells, quinacrine has
recently been proposed as a treatment for Creutzfeldt-Jakob disease (CJD), including a new …

Tetracyclines have been used to treat many bacterial infections. The use of these antibiotics
for the treatment of viral diseases dates to the 1960s to 1970s. Over the decades, the effect …