Aromatic interactions by molecular tweezers and clips in chemical and biological systems
FG Klärner, T Schrader - Accounts of chemical research, 2013 - ACS Publications
Noncovalent interactions involving aromatic rings, such as π-stacking and CH− π, occur
throughout a range of fundamental processes including self-assembly and (bio) catalysis …
throughout a range of fundamental processes including self-assembly and (bio) catalysis …
The IC50 concept revisited
GW Caldwell, Z Yan, W Lang… - Current topics in …, 2012 - ingentaconnect.com
A major strategy used in drug design is the inhibition of enzyme activity. The ability to
accurately measure the concentration of the inhibitor which is required to inhibit a given …
accurately measure the concentration of the inhibitor which is required to inhibit a given …
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
Allostery is an inherent feature of proteins, but it remains challenging to reveal the
mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic …
mechanisms by which allosteric signals propagate. A clearer understanding of this intrinsic …
[كتاب][B] Kinetic modeling of reactions in foods
MAJS Van Boekel - 2008 - taylorfrancis.com
The level of quality that food maintains as it travels down the production-to-consumption
path is largely determined by the chemical, biochemical, physical, and microbiological …
path is largely determined by the chemical, biochemical, physical, and microbiological …
Postprandial hyperglycemia lowering effect of the isolated compounds from olive mill wastes–An inhibitory activity and kinetics studies on α-glucosidase and α …
In the present study, we isolated seven compounds from olive mill wastes (OMW), one of
them being novel, and investigated their antidiabetic potential through inhibition of α …
them being novel, and investigated their antidiabetic potential through inhibition of α …
PfCRT mutations conferring piperaquine resistance in falciparum malaria shape the kinetics of quinoline drug binding and transport
The chloroquine resistance transporter (PfCRT) confers resistance to a wide range of
quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug …
quinoline and quinoline-like antimalarial drugs in Plasmodium falciparum, with local drug …
Insights into the inhibitory activities of neolignans and diarylnonanoid derivatives from nutmeg (Myristica fragrans Houtt.) seeds on soluble epoxide hydrolase using in vitro and …
Two new neolignans, myrifralignans F–G (14 and 18), four new diarylnonanoid derivatives,
myrifragranones A–D (21–24), and 18 known compounds were isolated and structurally …
myrifragranones A–D (21–24), and 18 known compounds were isolated and structurally …
Kinetic studies with alkaline phosphatase in the presence and absence of inhibitors and divalent cations
RL Dean - Biochemistry and Molecular Biology Education, 2002 - Wiley Online Library
A very robust and inexpensive kinetic assay for determining rates of hydrolysis of p‐
nitrophenyl phosphate by the enzyme alkaline phosphatase is presented. The reaction …
nitrophenyl phosphate by the enzyme alkaline phosphatase is presented. The reaction …
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition
INTRODUCTION Mycobacterium tuberculosis (Mtb) is the leading global cause of lethal
infection in humans and accounts for the largest number of drug-resistant infections by a …
infection in humans and accounts for the largest number of drug-resistant infections by a …
Inhibition of the facilitative sugar transporters (GLUTs) by tea extracts and catechins
D Ni, Z Ai, D Munoz‐Sandoval, R Suresh… - The FASEB …, 2020 - Wiley Online Library
Tea polyphenolics have been suggested to possess blood glucose lowering properties by
inhibiting sugar transporters in the small intestine and improving insulin sensitivity. In this …
inhibiting sugar transporters in the small intestine and improving insulin sensitivity. In this …