Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark
pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary …

Abstract Properties of human brain tissue change across the lifespan. Here we model these
changes in the living human brain by combining quantitative magnetic resonance imaging …

Cerebral white matter hyperintensities (WMH), detected in vivo with magnetic resonance
imaging (MRI), are commonly used to assess cerebrovascular burden in cognitive …

The human brain undergoes dramatic structural change over the life span. In a large
imaging cohort of 801 individuals aged 7–84 years, we applied quantitative relaxometry and …

The few extant reports of longitudinal white matter (WM) changes in healthy aging, using
diffusion tensor imaging (DTI), reveal substantial differences in change across brain regions …

Post-mortem and imaging studies have observed that white matter (WM) degenerates in a
pattern inverse to myelin development, suggesting preferential regional vulnerabilities …

Background: Alzheimer's disease (AD) is a widespread neurodegenerative disorder
characterized by progressive cognitive decline, affecting a significant portion of the aging …

Alzheimer's disease (AD) is the most common cause of dementia. A genome‐wide
association study has shown that several AD risk genes are involved in lipid metabolism …

Background: Conventional neuroimaging biomarkers for the neurodegeneration of
Alzheimer's disease (AD) are not sensitive enough to detect neurodegenerative alterations …

Automated classification of dementia stage using imaging will be useful for clinical diagnosis
and the classification accuracy will be biased for highly imbalanced samples in each class …