Death receptors: signaling and modulation
REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
S Von Karstedt, A Montinaro, H Walczak - Nature Reviews Cancer, 2017 - nature.com
The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …
Safety and antitumor activity of recombinant soluble Apo2 ligand
A Ashkenazi, RC Pai, S Fong, S Leung… - The Journal of …, 1999 - Am Soc Clin Investig
TNF and Fas ligand induce apoptosis in tumor cells; however, their severe toxicity toward
normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) …
normal tissues hampers their application to cancer therapy. Apo2 ligand (Apo2L, or TRAIL) …
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
JG Emery, P McDonnell, MB Burke, KC Deen… - Journal of Biological …, 1998 - ASBMB
TRAIL is a tumor necrosis factor-related ligand that induces apoptosis upon binding to its
death domain-containing receptors, DR4 and DR5. Two additional TRAIL receptors …
death domain-containing receptors, DR4 and DR5. Two additional TRAIL receptors …
Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries
A Montinaro, H Walczak - Cell Death & Differentiation, 2023 - nature.com
Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …
Apoptosis control by death and decoy receptors
The death receptors Fas and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis
upon engagement by their cognate death ligands. Recently, researchers have discovered …
upon engagement by their cognate death ligands. Recently, researchers have discovered …
Proteases to die for
Apoptosis or programmed cell death (PCD) is a genetically regulated, cellular suicide
mechanism that plays a crucial role in development and in the defense of homeostasis …
mechanism that plays a crucial role in development and in the defense of homeostasis …
Getting TRAIL back on track for cancer therapy
JV Lemke, S von Karstedt, J Zinngrebe… - Cell Death & …, 2014 - nature.com
Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …
Apo2L/TRAIL and its death and decoy receptors
HN LeBlanc, A Ashkenazi - Cell Death & Differentiation, 2003 - nature.com
Apo2 ligand or tumour necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
Oxidative stress and apoptosis: impact on cancer therapy
T Ozben - Journal of pharmaceutical sciences, 2007 - Elsevier
It is well established that some chemotherapeutic agents and radiation therapy generate
reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly …
reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly …