[HTML][HTML] Pore-forming toxins: ancient, but never really out of fashion
Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …
Marine natural products
Covering: 2002. Previous review: Nat. Prod. Rep., 2003, 20, 1 This review covers the
literature published in 2002 for marine natural products, with 579 citations (413 for the …
literature published in 2002 for marine natural products, with 579 citations (413 for the …
[HTML][HTML] Pore-forming protein toxins: from structure to function
MW Parker, SC Feil - Progress in biophysics and molecular biology, 2005 - Elsevier
Pore-forming protein toxins (PFTs) are one of Nature's most potent biological weapons. An
essential feature of their toxicity is the remarkable property that PFTs can exist either in a …
essential feature of their toxicity is the remarkable property that PFTs can exist either in a …
Biological functions of sphingomyelins
JP Slotte - Progress in lipid research, 2013 - Elsevier
Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …
Cytolytic peptide and protein toxins from sea anemones (Anthozoa: Actiniaria)
More than 32 species of sea anemones have been reported to produce lethal cytolytic
peptides and proteins. Based on their primary structure and functional properties, cytolysins …
peptides and proteins. Based on their primary structure and functional properties, cytolysins …
A common toxin fold mediates microbial attack and plant defense
C Ottmann, B Luberacki, I Küfner… - Proceedings of the …, 2009 - National Acad Sciences
Many plant pathogens secrete toxins that enhance microbial virulence by killing host cells.
Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In …
Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In …
Crystal and electron microscopy structures of sticholysin II actinoporin reveal insights into the mechanism of membrane pore formation
Sticholysin II (StnII) is a pore-forming protein (PFP) produced by the sea anemone
Stichodactyla helianthus. We found out that StnII exists in a monomeric soluble state but …
Stichodactyla helianthus. We found out that StnII exists in a monomeric soluble state but …
[HTML][HTML] Pore formation by actinoporins, cytolysins from sea anemones
Actinoporins (APs) from sea anemones are~ 20 kDa pore forming toxins with a β-sandwich
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …
Two-step membrane binding by Equinatoxin II, a pore-forming toxin from the sea anemone, involves an exposed aromatic cluster and a flexible helix
Equinatoxin II (EqtII) belongs to a unique family of 20-kDa pore-forming toxins from sea
anemones. These toxins preferentially bind to membranes containing sphingomyelin and …
anemones. These toxins preferentially bind to membranes containing sphingomyelin and …
Structural basis of the pore-forming toxin/membrane interaction
Y Li, Y Li, HM Mengist, C Shi, C Zhang, B Wang, T Li… - Toxins, 2021 - mdpi.com
With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative
therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence …
therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence …