Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

The discovery of genetic forms of Parkinson's disease (PD) has highlighted the importance
of the autophagy/lysosomal and mitochondrial/oxidative stress pathways in disease …

Cell membranes become highly curved during membrane trafficking, cytokinesis, infection,
immune response, or cell motion. Bin/amphiphysin/Rvs (BAR) domain proteins with their …

Synapses are often far from the soma and independently cope with proteopathic stress
induced by intense neuronal activity. However, how presynaptic compartments turn over …

Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-
mediated endocytosis (CME) is the housekee** pathway in resting cells but additional …

Membrane scission is essential for intracellular trafficking. While BAR domain proteins such
as endophilin have been reported in dynamin-independent scission of tubular membrane …

Many cellular processes rely on precise and timely deformation of the cell membrane. While
many proteins participate in membrane resha** and scission, usually in highly specialized …

Amphipathic helices (AHs), a secondary feature found in many proteins, are defined by their
structure and by the segregation of hydrophobic and polar residues between two faces of …

Lipids are the most abundant organic compounds in the brain. The brain has a unique
lipidome, and changes in lipid concentration, organization, and metabolism are associated …

A specific group of transmembrane receptors, including the β1-adrenergic receptor (β1-AR),
is internalized through a non-clathrin pathway known as Fast Endophilin Mediated …