[HTML][HTML] In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers

P Samakkarnthai, D Saul, L Zhang, Z Aversa… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
In addition to reducing fracture risk, zoledronic acid has been found in some studies to
decrease mortality in humans and extend lifespan and healthspan in animals. Because …

Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice

MC Trolese, C Scarpa, V Melfi, P Fabbrizio, F Sironi… - Molecular Therapy, 2022 - cell.com
Monocyte chemoattractant protein-1 (MCP1) is one of the most powerful pro-inflammatory
chemokines. However, its signaling is pivotal in driving injured axon and muscle …

Quantifying the recovery process of skeletal muscle on hematoxylin and eosin stained images via learning from label proportion

Y Yamaoka, WI Chan, S Seno, K Iwamori, S Fukada… - Scientific Reports, 2024 - nature.com
Visual observing muscle tissue regeneration is used to measure experimental effect size in
biological research to discover the mechanism of muscle strength decline due to illness or …

Older mice show decreased regeneration of neuromuscular junctions following lengthening contraction-induced injury

TA Paul, PC Macpherson, TL Janetzke, CS Davis… - Geroscience, 2023 - Springer
Progressive muscle atrophy and loss of muscle strength associated with old age have been
well documented. Although age-associated impairments in skeletal muscle regeneration …

Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice

P Fabbrizio, J D'Agostino, C Margotta, G Mella… - Cellular and Molecular …, 2022 - Springer
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder that leads to progressive
degeneration of motor neurons and severe muscle atrophy without effective treatment. Most …

Enduring effects of acute prenatal ischemia in rat soleus muscle, and protective role of erythropoietin

T Sancerni, V Montel, J Dereumetz, L Cochon… - Journal of Muscle …, 2024 - Springer
Motor disorders are considered to originate mainly from brain lesions. Placental dysfunction
or maternal exposure to a persistently hypoxic environment is a major cause of further motor …

Targeted-SMN insufficiency in Skeletal Muscle Stem Cells mediates non-cell autonomous loss of motor neurons at long term

J Mecca, J Mignot, M Gervais, T Ozturk, S Astord… - bioRxiv, 2024 - biorxiv.org
Spinal Muscular Atrophy (SMA) is due to a deficit in SMN protein encoded by the SMN1
gene. SMN-targeted disease modifying treatments have greatly improved the clinical …

Two new reliable immunohistochemical methods for simultaneous identification of capillaries, the three types of fibers and basal lamina in human skeletal muscle

M Bailly, L Féasson, B Pereira, A Boileau… - Histochemistry and Cell …, 2020 - Springer
Capillary network of skeletal muscle has a crucial role in oxygen supply and is strongly
associated with the phenotype and metabolic profile of muscle fibers. Abundant literature …

Regulation of Muscle Stem Cell Quiescence by Niche Adhesion

M Hung - 2023 - search.proquest.com
The regenerative capacity of skeletal muscle is attributed to a small population of quiescent
muscle stem cells, or MuSCs. Conditional removal of both N-and M-cadherin from the MuSC …