The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

The importance of protein glycosylation in the migration of immune cells throughout the body
has been extensively appreciated. However, our awareness of the impact of glycosylation …

Colorectal cancer (CRC) represents the third most common malignancy and the second
leading cause of cancer-related deaths worldwide. Although immunotherapy has taken …

Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

A successful pregnancy requires synchronized adaptation of maternal immune-endocrine
mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan …

Inflammation-mediated neurodegeneration occurs in the acute and the chronic phases of
multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis …

Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Programmed remodeling of cell surface glycans by the sequential action of specific
glycosyltransferases can control biological processes by generating or masking ligands for …

Glycosylation is a common posttranslational modification of proteins and lipids of the
secretory pathway that generates binding sites for galactose-specific lectins or galectins …