The intestinal microflora is a positive health asset that crucially influences the normal
structural and functional development of the mucosal immune system. Mucosal immune …

The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are
common causes of gastrointestinal disease in northern Europe, affecting as many as one in …

In recent years, investigators have readdressed the complex issues involved in the
classification of inflammatory bowel diseases. In 2003, a Working Party of investigators with …

BACKGROUND AND AIMS: Antibodies directed against the porin protein C of Escherichia
coli (anti-OmpC) and Pseudomonas fluorescens (anti-I2) have recently been described in …

Background & Aims: Recent studies suggest that the mouth may be involved frequently in
patients with Crohn's disease (CD). The aim of this study was to document prospectively the …

The search for susceptibility genes had its first success in 1996, when the first susceptibility
locus for CD was identified in the pericentromeric region of chromosome 16, which was …

NOD2/caspase recruitment domain (CARD) 15 variants are identified in up to 50% of
Crohn's disease (CD) patients. Functional variants of toll-like receptor-4 (TLR4) and CD14 …

OBJECTIVES: Crohn's disease (CD) is characterized by overproduction of proinflammatory
cytokines like interleukin (IL)-1β. Production of mature IL-1β is dependent on a caspase-1 …

The resident microbiota of the human intestine exerts a conditioning effect on intestinal
homeostasis, delivering regulatory signals to the epithelium and instructing mucosal …

Crohn's disease and ulcerative colitis result from an inappropriate response of the mucosal
immune system to the normal enteric flora in a genetically susceptible individual. During the …