Targeting α7 nicotinic acetylcholine receptors and their protein interactions in Alzheimer's disease drug development
LH Burns, Z Pei, HY Wang - Drug Development Research, 2023 - Wiley Online Library
The decades‐old cholinergic hypothesis of Alzheimer's disease (AD) led to clinical testing
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …
A neuropsychological perspective on defining cognitive impairment in the clinical study of Alzheimer's disease: Towards a more continuous approach
The global fight against Alzheimer's disease (AD) poses unique challenges for the field of
neuropsychology. Along with the increased focus on early detection of AD pathophysiology …
neuropsychology. Along with the increased focus on early detection of AD pathophysiology …
Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine
receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of …
receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of …
EEG‐Based Spectral Dynamic in Characterization of Poststroke Patients with Cognitive Impairment for Early Detection of Vascular Dementia
One common type of vascular dementia (VaD) is poststroke dementia (PSD). Vascular
dementia can occur in one‐third of stroke patients. The worsening of cognitive function can …
dementia can occur in one‐third of stroke patients. The worsening of cognitive function can …
Molecular Signaling Pathways of Quercetin in Alzheimer's Disease: A Promising Arena
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive
impairment and memory deficit. Even with extensive research and studies, presently, there is …
impairment and memory deficit. Even with extensive research and studies, presently, there is …
The relationship between cerebral and retinal microbleeds in cerebral amyloid angiopathy (CAA): A pilot study
Background The standard in vivo diagnostic imaging technique for cerebral amyloid
angiopathy (CAA) is costly and thereby of limited utility for point-of-care diagnosis and …
angiopathy (CAA) is costly and thereby of limited utility for point-of-care diagnosis and …
[HTML][HTML] TMS-derived short afferent inhibition discriminates cognitive status in older adults without dementia
Aging is a complex and diverse biological process characterized by progressive molecular,
cellular, and tissue damage, resulting in a loss of physiological integrity and heightened …
cellular, and tissue damage, resulting in a loss of physiological integrity and heightened …
Characterizing the Neurophysiological Correlates of Age-Related Cognitive Decline with Corticomotor Transcranial Magnetic Stimulation
M Sundman - 2022 - search.proquest.com
The field of Alzheimer's Disease and Related Dementia (ADRD) is currently in a state of flux,
with a push to disarticulate the pathobiological and clinico-behavioral facets of the disease …
with a push to disarticulate the pathobiological and clinico-behavioral facets of the disease …