Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Linear d‐glucans are natural polysaccharides of simple chemical structure. They are
comprised of d‐glucosyl units linked by a single type of glycosidic bond. Noncovalent …

Herein we utilise automated glycan assembly to complete solid-phase synthesis of defined
heparan sulfate oligosaccharides, employing challenging D-glucuronate disaccharide …

Natural heparin, a glycosaminoglycan consisting of repeating hexuronic acid and
glucosamine linked by 1→ 4 glycosidic bonds, is the most widely used anticoagulant. To …

Abstract Low Molecular Weight Heparins (LMWHs) are well-established for use in the
prevention and treatment of thrombotic diseases, and as a substitute for unfractionated …

Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS
oligosaccharides bearing systematically varied sulfation structures are available owing to …

Abstract Highly stereoselective synthesis of 1, 2-cis glycosides remains a challenging task
due to the lack of reliable neighboring group participation (NGP) from the 2-O-acyl …

Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of
thrombotic diseases, displays better efficacy and biosafety than other heparin-based …

Reported herein is a scalable chemical synthesis of disaccharide building blocks for
heparan sulfate (HS) oligosaccharide assembly. The use of d-glucuronate-based acceptors …