The heart is responsible for pum** blood throughout the blood vessels to the periphery by
repeated, rhythmic contractions at variable intensity. As such the heart should permanently …

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical,
organizational and signaling roles. Because many cytoskeletal proteins are sensitive to …

Mitochondria are involved in cellular functions that go beyond the traditional role of these
organelles as the power plants of the cell. Mitochondria have been implicated in several …

BACKGROUND: Cachexia is a wasting condition that manifests in several types of cancer,
and the main characteristic is the profound loss of muscle mass. METHODS: The Yoshida …

Doxorubicin is a chemotherapeutic agent known to cause cardiotoxicity that is thought to be
associated with oxidative stress. The aim of the current study is to investigate the role of …

As sarcomeres produce the force necessary for contraction, assessment of sarcomere order
is paramount in evaluation of cardiac and skeletal myocytes. The uniaxial force produced by …

Cancer cachexia is a highly debilitating paraneoplastic disease observed in more than 50%
of patients with advanced cancers and directly contributes to 20% of cancer deaths. Loss of …

Myofibrillary myopathies (MFM) are hereditary myopathies histologically characterized by
degeneration of myofibrils and aggregation of proteins in striated muscle. Cardiomyopathy is …

Transmission electron microscopy (TEM) has long been an important technique, capable of
high degree resolution and visualization of subcellular structures and organization. Over the …

Mitochondria are central to cellular energy production and metabolic regulation, particularly
in cardiomyocytes. These organelles constantly undergo cycles of fusion and fission …