This article investigates the role of recent advances in Artificial Intelligence (AI) to
revolutionise the study of G protein-coupled receptors (GPCRs). AI has been applied to …

While drug combination therapies are of great importance, particularly in cancer treatment,
identifying novel synergistic drug combinations has been a challenging venture …

The greatest challenge in drug discovery remains the high rate of attrition across the
different phases of the process, which cost the industry billions of dollars every year. While …

Iridoids commonly found in plants as secondary metabolites have been reported to possess
significant biological activities such as anticancer, antioxidant, hypoglycemic, antimicrobial …

Target identification is a critical stage in the drug discovery pipeline. Various computational
methodologies have been dedicated to enhancing the classification performance of …

Kinases play a vital role in regulating essential cellular processes, including cell cycle
progression, growth, apoptosis, and metabolism, by catalyzing the transfer of phosphate …

Proteins interact through their interfaces, and dysfunction of protein–protein interactions
(PPIs) has been associated with various diseases. Therefore, investigating the properties of …

The calculation of binding affinity is a crucial aspect in the development of new drugs,
however, it is a costly and time-consuming process. By creating a predictive model for the …