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Click chemistry strategies for the accelerated synthesis of functional macromolecules
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …
materials with precise control over architecture and functionality. In this review, we provide a …
[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …
biohybrid materials which combine advantages from both the synthetic world and Nature …
Chemical technology principles for selective bioconjugation of proteins and antibodies
Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …
component of a living system. Hence, control over their bioconjugation impacts science at …
Dual pH-/thermo-responsive chitosan-based hydrogels prepared using" click" chemistry for colon-targeted drug delivery applications
A dual pH-/thermo-responsive hydrogel was designed based on a polyelectrolyte complex
of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was …
of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was …
Chemical and enzymatic methods for post-translational protein–protein conjugation
RJ Taylor, MB Geeson, T Journeaux… - Journal of the …, 2022 - ACS Publications
Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …
A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design
JH Ko, HD Maynard - Chemical Society Reviews, 2018 - pubs.rsc.org
Proteins are an important class of therapeutics that have advantages including high target
specificity, but challenges to their use include rapid clearance and low physical stability …
specificity, but challenges to their use include rapid clearance and low physical stability …
Controlled radical polymerization as an enabling approach for the next generation of protein–polymer conjugates
EM Pelegri-O'Day, HD Maynard - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus Protein–polymer conjugates are unique constructs that combine the chemical
properties of a synthetic polymer chain with the biological properties of a biomacromolecule …
properties of a synthetic polymer chain with the biological properties of a biomacromolecule …
Glycopolymer and poly (β-amino ester)-based amphiphilic block copolymer as a drug carrier
Glycopolymers are synthetic macromolecules having pendant sugar moieties and widely
utilized to target cancer cells. They are usually considered as a hydrophilic segment of …
utilized to target cancer cells. They are usually considered as a hydrophilic segment of …
Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1,2,4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes
Aligned with the increasing importance of bioorthogonal chemistry has been an increasing
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …
Energetic Trinitro‐and Fluorodinitroethyl Ethers of 1, 2, 4, 5‐Tetrazines
DE Chavez, DA Parrish… - Angewandte Chemie …, 2016 - Wiley Online Library
Several new energetic ethyl ethers of 1, 2, 4, 5‐tetrazine have been synthesized. These
molecules display good thermal stability, good oxygen balance, and high densities. Included …
molecules display good thermal stability, good oxygen balance, and high densities. Included …