Click chemistry strategies for the accelerated synthesis of functional macromolecules

Z Geng, JJ Shin, Y **, CJ Hawker - Journal of Polymer Science, 2021 - Wiley Online Library
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

[HTML][HTML] Polymer bioconjugates: Modern design concepts toward precision hybrid materials

C Chen, DYW Ng, T Weil - Progress in Polymer Science, 2020 - Elsevier
The conjugation of synthetic polymers with various biomolecules provides an easy access to
biohybrid materials which combine advantages from both the synthetic world and Nature …

Chemical technology principles for selective bioconjugation of proteins and antibodies

P Chauhan, V Ragendu, M Kumar, R Molla… - Chemical Society …, 2024 - pubs.rsc.org
Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Dual pH-/thermo-responsive chitosan-based hydrogels prepared using" click" chemistry for colon-targeted drug delivery applications

HT Hoang, SH Jo, QT Phan, H Park, SH Park… - Carbohydrate …, 2021 - Elsevier
A dual pH-/thermo-responsive hydrogel was designed based on a polyelectrolyte complex
of polyacrylic acid (PAA) and norbornene-functionalized chitosan (CsNb), which was …

Chemical and enzymatic methods for post-translational protein–protein conjugation

RJ Taylor, MB Geeson, T Journeaux… - Journal of the …, 2022 - ACS Publications
Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

A guide to maximizing the therapeutic potential of protein–polymer conjugates by rational design

JH Ko, HD Maynard - Chemical Society Reviews, 2018 - pubs.rsc.org
Proteins are an important class of therapeutics that have advantages including high target
specificity, but challenges to their use include rapid clearance and low physical stability …

Controlled radical polymerization as an enabling approach for the next generation of protein–polymer conjugates

EM Pelegri-O'Day, HD Maynard - Accounts of Chemical Research, 2016 - ACS Publications
Conspectus Protein–polymer conjugates are unique constructs that combine the chemical
properties of a synthetic polymer chain with the biological properties of a biomacromolecule …

Glycopolymer and poly (β-amino ester)-based amphiphilic block copolymer as a drug carrier

EL Sahkulubey Kahveci, MU Kahveci, A Celebi… - …, 2022 - ACS Publications
Glycopolymers are synthetic macromolecules having pendant sugar moieties and widely
utilized to target cancer cells. They are usually considered as a hydrophilic segment of …

Advances in the Synthesis of Bioorthogonal Reagents: s-Tetrazines, 1,2,4-Triazines, Cyclooctynes, Heterocycloheptynes, and trans-Cyclooctenes

Y Fang, AS Hillman, JM Fox - Topics in Current Chemistry, 2024 - Springer
Aligned with the increasing importance of bioorthogonal chemistry has been an increasing
demand for more potent, affordable, multifunctional, and programmable bioorthogonal …

Energetic Trinitro‐and Fluorodinitroethyl Ethers of 1, 2, 4, 5‐Tetrazines

DE Chavez, DA Parrish… - Angewandte Chemie …, 2016 - Wiley Online Library
Several new energetic ethyl ethers of 1, 2, 4, 5‐tetrazine have been synthesized. These
molecules display good thermal stability, good oxygen balance, and high densities. Included …