Prokaryotic Argonautes (pAgos) are an emerging class of programmable endonucleases
that are believed to be more flexible than existing CRISPR–Cas systems and have …

Abstract Proksee (https://proksee. ca) provides users with a powerful, easy-to-use, and
feature-rich system for assembling, annotating, analysing, and visualizing bacterial …

Identifying and characterizing mobile genetic elements in sequencing data is essential for
understanding their diversity, ecology, biotechnological applications and impact on public …

More than three billion years of evolution have produced an image of biology encoded into
the space of natural proteins. Here we show that language models trained at scale on …

The Lachnospiraceae is a family of anaerobic bacteria in the class Clostridia with potential
to advance the bio-economy and intestinal therapeutics. Some species of Lachnospiraceae …

Plasmids are mobile genetic elements found in many clades of Archaea and Bacteria. They
drive horizontal gene transfer, impacting ecological and evolutionary processes within …

Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host
molecules as a means of antiviral defence,,,–. Here we studied an antiphage defence …

Consortia of multicellular magnetotactic bacteria (MMB) are currently the only known
example of bacteria without a unicellular stage in their life cycle. Because of their …

Secondary metabolites are compounds not essential for an organism's development, but
provide significant ecological and physiological benefits. These compounds have …

Following 30 years of sequencing, we assessed the phylogenetic diversity (PD) of> 1.5
million microbial genomes in public databases, including metagenome-assembled …