The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and
dynamic. Various features of the nuclear architecture, including compartmentalization of …

The family of Hox genes, which number 4 to 48 per genome depending on the animal,
control morphologies on the main body axis of nearly all metazoans. The conventional …

Gene regulatory networks are the most complex, extensive control systems found in nature.
The interaction between biology and evolution has been the subject of great interest in …

The control of gene expression involves regulatory elements that can be very far from the
genes they control. Several recent technological advances have allowed the direct detection …

The amphipod crustacean Parhyale hawaiensis is a blossoming model system for studies of
developmental mechanisms and more recently regeneration. We have sequenced the …

In Drosophila, the function of the Polycomb group genes (PcGs) and their target sequences
(Polycomb response elements (PREs)) is to convey mitotic heritability of transcription …

Histone post-translational modifications (PTMs) are associated with epigenetic states that
form the basis for cell-type-specific gene expression,. Once established, histone PTMs can …

Crustaceans possess a diverse array of specialized limbs. Although shifts in Hox gene
expression domains have been postulated to play a role in generating this limb diversity …

MicroRNAs (miRNAs) are an extensive class of regulatory RNA whose specific functions in
animals are generally unknown. Although computational methods have identified many …

It is usually thought that the development of complex organisms is controlled by protein
regulatory factors and morphogenetic signals exchanged between cells and differentiating …