Many gene defects are relatively easy to identify experimentally, but obtaining information
about the effects of sequence variations and elucidation of the detailed molecular …

The genomic era has been characterised by vast amounts of data from diverse sources,
creating a need for new tools to extract biologically meaningful information. Bioinformatics is …

Background The relationship between disease susceptibility and genetic variation is
complex, and many different types of data are relevant. We describe a web resource and …

The Protein Data Bank (PDB; http://wwpdb. org) was established in 1971 as the first open
access digital data resource in biology with seven protein structures as its initial holdings …

The study of DNA sequence variation has been transformed by recent advances in DNA
sequencing technologies. Determination of the functional consequences of sequence …

Computational biology has the opportunity to play an important role in the identification of
functional single nucleotide polymorphisms (SNPs) discovered in large-scale genoty** …

In today's research environment, a wealth of experimental/theoretical structural data is
available and the number of therapeutically relevant macromolecular structures is growing …

A versatile method to directly identify and analyze short-or long-range coupled or
communicating residues in a protein conformational ensemble is of extreme relevance to …

Identification and annotation of mutated genes or proteins involved in oncogenesis and
tumor progression are crucial for both cancer biology and clinical applications. We have …

Mutations in the fibrinogen gamma chain (FGG) gene have been associated with various
disorders, such as dysfibrinogenemia, thrombophilia, and hypofibrinogenemia. A literature …