Misfolding and aggregation in neurodegenerative diseases: Protein quality control machinery as potential therapeutic clearance pathways

O Koszła, P Sołek - Cell Communication and Signaling, 2024 - Springer
The primary challenge in today's world of neuroscience is the search for new therapeutic
possibilities for neurodegenerative disease. Central to these disorders lies among other …

Structured long-chain omega-3 fatty acids for improvement of cognitive function during aging

I Mora, L Arola, A Caimari, X Escoté… - International journal of …, 2022 - mdpi.com
Although the human lifespan has increased in the past century owing to advances in
medicine and lifestyle, the human healthspan has not kept up the same pace, especially in …

D-Pinitol—active natural product from carob with notable insulin regulation

A Azab - Nutrients, 2022 - mdpi.com
Carob is one of the major food trees for peoples of the Mediterranean basin, but it has also
been traditionally used for medicinal purposes. Carob contains many nutrients and active …

Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease

AL Turcu, J Companys-Alemany, MB Phillips… - European journal of …, 2022 - Elsevier
Currently, of the few accessible symptomatic therapies for Alzheimer's disease (AD),
memantine is the only N-methyl-d-aspartate receptor (NMDAR) blocker approved by the …

D-pinitol ameliorated H2O2-induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans

M Zhang, Z Xu, L Shao, J Wang, Z He, Y Jiang… - … and Physiology Part C …, 2023 - Elsevier
D-pinitol (DP) has been extensively regarded as the main active component of legumes for
anti-aging. In this study, we intended to explore the anti-aging mechanism of DP, utilizing …

[HTML][HTML] Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

W Kleawyothatis, P Jattujan, K Chumphoochai… - Journal of Traditional …, 2023 - Elsevier
Background and aim Alzheimer's disease (AD) is the most common aged-related
neurodegenerative disorder that is associated with the toxic amyloid-β (Aβ) aggregation in …

Anti-Alzheimer Potential of a New (+)-Pinitol Glycoside Isolated from Tamarindus indica Pulp: In Vivo and In Silico Evaluations

EM Mohamed, A H. Elmaidomy, R Alaaeldin… - Metabolites, 2023 - mdpi.com
Tamarindus indica Linn (tamarind, F. Leguminosae) is one of the most widely consumed
edible fruits in the world. Phytochemical investigation of tamarind pulp n-butanol fraction …

Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans

I Mora, A Pérez-Santamaria, J Tortajada-Pérez… - Cells, 2023 - mdpi.com
The human lifespan has increased over the past century; however, healthspans have not
kept up with this trend, especially cognitive health. Among nutrients for brain function …

[HTML][HTML] Current Advances and Future Perspectives on Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease

W Zhang, R Uyemura, K Zhong, R Guo… - Aging and …, 2024 - pmc.ncbi.nlm.nih.gov
The incidence of Alzheimer's disease (AD) has been increasing in recent years as the
world's population ages, which poses a significant challenge to public health. Due to the …

Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression

SR Kopalli, T Behl, A Kyada, MM Rekha, M Kundlas… - Neuroscience, 2025 - Elsevier
Flavonoids are a broad family of polyphenolic chemicals that are present in a wide variety of
fruits, vegetables, and medicinal plants. Because of their neuroprotective qualities …