Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane, T Shea-Donohue - The Journal of clinical …, 2021 - jci.org
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

H Wu, J Zheng, S Xu, Y Fang, Y Wu, J Zeng… - Journal of …, 2021 - Springer
Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

The chronic and evolving neurological consequences of traumatic brain injury

L Wilson, W Stewart, K Dams-O'Connor… - The Lancet …, 2017 - thelancet.com
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.
Research on the long-term consequences emphasises that, for many patients, TBI should be …

Traumatic brain injury: Mechanisms, manifestations, and visual sequelae

SH Rauchman, A Zubair, B Jacob… - Frontiers in …, 2023 - frontiersin.org
Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

Severe traumatic brain injury: targeted management in the intensive care unit

N Stocchetti, M Carbonara, G Citerio, A Ercole… - The Lancet …, 2017 - thelancet.com
Severe traumatic brain injury (TBI) is currently managed in the intensive care unit with a
combined medical–surgical approach. Treatment aims to prevent additional brain damage …

[HTML][HTML] Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction

M Kodali, LN Madhu, RL Reger, B Milutinovic… - Brain, behavior, and …, 2023 - Elsevier
Traumatic brain injury (TBI) leads to lasting brain dysfunction with chronic
neuroinflammation typified by nucleotide-binding domain leucine-rich repeat and pyrin …

[HTML][HTML] Accuracy of EEG biomarkers in the detection of clinical outcome in disorders of consciousness after severe acquired brain injury: preliminary results of a pilot …

F Di Gregorio, F La Porta, V Petrone, S Battaglia… - Biomedicines, 2022 - mdpi.com
Accurate outcome detection in neuro-rehabilitative settings is crucial for appropriate long-
term rehabilitative decisions in patients with disorders of consciousness (DoC). EEG …

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

AIR Maas, DK Menon, PD Adelson, N Andelic… - The Lancet …, 2017 - thelancet.com
Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …

Extracellular vesicles derived from neural stem cells, astrocytes, and microglia as therapeutics for easing TBI-induced brain dysfunction

C Hering, AK Shetty - Stem cells translational medicine, 2023 - academic.oup.com
Extracellular vesicles (EVs) derived from neural stem cells (NSC-EVs), astrocytes (ADEVs),
and microglia (MDEVs) have neuroregenerative properties. This review discusses the …