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1. Background Liver transplantation significantly improves the survival and quality of life of
patients with end-stage cirrhosis. However, a large proportion of cirrhotic patients still die …

The first human orthotopic liver transplantation (LT) in Europe was performed by Sir Roy
Calne in Cambridge in 1968 [1], only one year after the first successful human liver …

Therapies to reduce liver fibrosis and stimulate organ regeneration are urgently needed. We
conducted a first-in-human, phase 1 dose-escalation trial of autologous macrophage …

Cirrhosis is defined as the histological development of regenerative nodules surrounded by
fibrous bands in response to chronic liver injury, which leads to portal hypertension and end …

Background: Prognosis in cirrhotic patients has had a resurgence of interest because of liver
transplantation and new therapies for complications of end‐stage cirrhosis. The model for …

Abstract The Model for End‐Stage Liver Disease (MELD) score is now used for allocation in
liver transplantation (LT) waiting lists, replacing the Child‐Turcotte‐Pugh (CTP) score …

Adoption of the Model for End-stage Liver Disease (MELD) to select and prioritize patients
for liver transplantation represented a turning point in organ allocation. Prioritization of …

Cirrhosis is a major cause of morbidity and mortality; however, there are no approved
therapies except orthotopic liver transplantation. Preclinical studies showed that bone …

Background Red blood cell distribution width (RDW), an automated measure of red blood
cell size heterogeneity (eg, anisocytosis) that is largely overlooked, is a newly recognized …