Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Bone defects resulting from trauma, illness or congenital abnormalities represent a
significant challenge to global health. Conventional treatments such as autographs and …

Mesenchymal stem cells (MSCs) have been identified in many adult tissues. MSCs can
regenerate through cell division or differentiate into adipocytes, osteoblasts and …

Stem cells are the central element of regenerative medicine (RM). However, in many clinical
applications, the use of scaffolds fabricated with biomaterials is required. In this sense …

Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of
gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with …

The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a
priority for patients affected by tooth loss, congenital defects, trauma deformities, or various …

Over the past decades, age-related pathologies have increased abreast the aging
population worldwide. The increased age of the population indicates that new tools, such as …

The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal
cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals …

Adipogenesis, osteogenesis and chondrogenesis of human mesenchymal stem/stromal
cells (MSC) are complex and highly regulated processes. Over the years, several studies …

Bone is a dynamic organ with high regenerative potential and provides essential biological
functions in the body, such as providing body mobility and protection of internal organs …