Highlights•Candidalysin is the first peptide toxin identified in any human fungal pathogen.•
Candidalysin is critical for Candida albicans mucosal and systemic infections.•Candidalysin …

Candida albicans is the most common fungal pathogen of humans and has developed an
extensive repertoire of putative virulence mechanisms that allows successful colonization …

Candida parapsilosis is an emerging major human pathogen that has dramatically
increased in significance and prevalence over the past 2 decades, such that C. parapsilosis …

The four major classes of protease enzymes1-4 (aspartic, serine, cysteine, and metallo)
selectively catalyze the hydrolysis of polypeptide bonds. Their control over protein synthesis …

Candida albicans is a facultative pathogenic micro‐organism that has developed several
virulence traits enabling invasion of host tissues and avoidance of host defence …

Discriminating between commensal and pathogenic states of opportunistic pathogens is
critical for host mucosal defense and homeostasis. The opportunistic human fungal …

Candida albicans interactions with epithelial cells are critical for commensal growth, fungal
pathogenicity and host defence. This review will outline our current understanding of C …

Many species of human pathogenic fungi secrete proteases in vitro or during the infection
process. Secreted endoproteases belong to the aspartic proteases of the pepsin family …

Candida infections are common, debilitating and often recurring fungal diseases and a
problem of significant clinical importance. Candida albicans, the most virulent of the …

Historically, the nature and extent of host damage by a microbe were considered highly
dependent on virulence attributes of the microbe. However, it has become clear that disease …