The chemokine system in innate immunity

CL Sokol, AD Luster - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Chemokines are chemotactic cytokines that control the migration and positioning of immune
cells in tissues and are critical for the function of the innate immune system. Chemokines …

Chemokines and chemokine receptors: positioning cells for host defense and immunity

JW Griffith, CL Sokol, AD Luster - Annual review of immunology, 2014 - annualreviews.org
Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

CCR4 and its ligands: from bench to bedside

O Yoshie, K Matsushima - International immunology, 2015 - academic.oup.com
Chemokines and chemokine receptors orchestrate cell migration and homing in the body.
Humans have at least 44 chemokines that are further classified into four subfamilies based …

The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Chemokines and leukocyte traffic

M Baggiolini - Nature, 1998 - nature.com
Over the past ten years, numerous chemokines have been identified as attractants of
different types of blood leukocytes to sites of infection and inflammation. They are produced …

T-cell subsets (Th1 versus Th2)

S Romagnani - Annals of allergy, asthma & immunology, 2000 - Elsevier
LEARNING OBJECTIVE: To understand the current status of knowledge in the basic field of
polarized specific immune responses mediated by CD4+ T helper (Th) lymphocytes, based …

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

S Qin, JB Rottman, P Myers, N Kassam… - The Journal of …, 1998 - Am Soc Clin Investig
T cells infiltrating inflammatory sites are usually of the activated/memory type. The precise
mechanism for the positioning of these cells within tissues is unclear. Adhesion molecules …

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

F Sallusto, D Lenig, CR Mackay… - The Journal of …, 1998 - rupress.org
Chemokines and their receptors are important elements for the selective attraction of various
subsets of leukocytes. To better understand the selective migration of functional subsets of T …

Eosinophilic gastrointestinal disorders (EGID)

ME Rothenberg - Journal of Allergy and Clinical Immunology, 2004 - Elsevier
Primary eosinophilic gastrointestinal disorders are defined as disorders that selectively
affect the gastrointestinal tract with eosinophil-rich inflammation in the absence of known …

Macrophage inflammatory protein-1

P Menten, A Wuyts, J Van Damme - Cytokine & growth factor reviews, 2002 - Elsevier
Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …