Post‐transcriptional gene silencing targets and degrades mRNA transcripts, silencing the
expression of specific genes. RNA interference technology, using synthetic structurally well …

Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …

Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …

Background and Purpose Astrocytic nuclear factor erythroid‐derived 2‐related factor 2 (Nrf2)
is a potential therapeutic target of ischaemic preconditioning (IPC). Icariside II (ICS II) is a …

Major depressive disorder is a leading cause of disability worldwide. Because conventional
therapies are ineffective in many patients, novel strategies are needed to overcome …

Background and Purpose Muscle protein catabolism in patients with diabetic nephropathy
(DN) results in striking loss of muscle proteins, which increases morbidity and mortality risks …

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …

Abstract Background and Purpose Membranous nephropathy (MN) is an immune‐mediated
glomerular disease in adults. Antibody‐and antigen‐bonding mechanisms have been …

Background and Purpose Mitochondrial damage and oxidative stress are crucial
contributors to the tubular cell injury and death in acute kidney injury. Novel therapeutic …

Background and Purpose Gut microbiota dysbiosis induced by acute pancreatitis (AP)
exacerbates pancreatic injury and systemic inflammatory responses. The alleviation of gut …