Early evaluation of treatment response and prediction of disease evolution are key issues in
the management of people with multiple sclerosis (MS). In the past 20 years, MRI has …

This review provides a qualitative and quantitative analysis of cerebral glucose metabolism
in ageing. We undertook a systematic literature review followed by pooled effect size and …

Objective Therapeutic development in progressive multiple sclerosis (PMS) has been
hampered by a lack of reliable biomarkers to monitor neurodegeneration. Optical coherence …

Neurodegeneration is one of the driving forces behind the pathogenesis of multiple sclerosis
(MS). Progression without activity, pathopsychological disturbances (cognitive impairment …

Abstract Machine learning can reliably predict individual age from MRI data, revealing that
patients with neurodegenerative disorders show an elevated biological age. A surprising …

Objective To describe the dynamics of brain volume loss (BVL) at different stages of
relapsing-remitting multiple sclerosis (RRMS), to describe the association between BVL and …

Gyrification of the cerebral cortex changes with aging and relates to development of
cognitive function during early life and midlife. Little is known about how gyrification relates …

Our goal was to determine the influence of sex, age and the head/brain size on the
compartmental brain volumes in the radiologically verified healthy population (96 subjects; …

Recurrent neuroinflammation in relapsing-remitting MS (RRMS) is thought to lead to
neurodegeneration, resulting in progressive disability. Repeated magnetic resonance …

Delirium is associated with long-term cognitive dysfunction and with increased brain
atrophy. However, it is unclear whether these problems result from or predisposes to …