Abstract Von Hippel–Lindau disease (vHL) is a hereditary tumor predisposition syndrome
that places affected individuals at risk for multiple tumors, which are predominantly benign …

The autosomal dominantly inherited disorder von Hippel–Lindau disease (VHL) is caused
by germline mutations in the VHL tumour suppressor gene (TSG). VHL mutations …

Summary von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is
associated with a germline mutation of the VHL tumour suppressor gene on the short arm of …

Hereditary cancer syndromes account for nearly 10% of cancers even though they are often
underdiagnosed. Finding a pathogenic gene variant could have dramatic implications in …

Purpose Genetic factors have been implicated in the pathogenesis of renal cell carcinoma
(RCC), with around 3% of cases having a family history. A greater knowledge of the genetics …

The differential diagnostic process attempts to identify candidate diseases that best explain
a set of clinical features. This process can be complicated by the fact that the features can …

Hypoxia acts as an important regulator of physiological and pathological processes.
Hypoxia inducible factors (HIFs) are the central players involved in the cellular adaptation to …

Pancreatic endocrine tumors (PETs) have long fascinated clini-cians, because some can
release biologically active hormones that cause distinct syndromes and provide important …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

Understanding of molecular mechanisms of tumor growth has an increasing impact on the
development of diagnostics and targeted therapy of human neoplasia. In this review, we …