Ewing sarcoma—diagnosis, treatment, clinical challenges and future perspectives
Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …
Ewing's sarcoma
N Riggi, ML Suvà, I Stamenkovic - New England Journal of …, 2021 - Mass Medical Soc
Ewing's Sarcoma Ewing's sarcoma, an aggressive cancer of bone and soft tissue, primarily
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
affects children and young adults. A t (11; 22) translocation is noted in 85 to 90% of cases …
Teprotumumab for thyroid-associated ophthalmopathy
TJ Smith, GJ Kahaly, DG Ezra… - … England Journal of …, 2017 - Mass Medical Soc
Background Thyroid-associated ophthalmopathy, a condition commonly associated with
Graves' disease, remains inadequately treated. Current medical therapies, which primarily …
Graves' disease, remains inadequately treated. Current medical therapies, which primarily …
A first-generation pediatric cancer dependency map
Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational-
burden adult cancers. A key question, however, is whether functional genomic approaches …
burden adult cancers. A key question, however, is whether functional genomic approaches …
Therapeutic targeting of the IGF axis
E Osher, VM Macaulay - Cells, 2019 - mdpi.com
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and
development, and when deregulated makes an important contribution to disease. Here, we …
development, and when deregulated makes an important contribution to disease. Here, we …
Current and future treatment strategies for rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
Common musculoskeletal tumors of childhood and adolescence
CAS Arndt, PS Rose, AL Folpe, NN Laack - Mayo Clinic Proceedings, 2012 - Elsevier
Osteosarcoma, Ewing sarcoma, and rhabdomyosarcoma are the most common malignant
musculoskeletal tumors in children and adolescents. Today, most patients can be cured …
musculoskeletal tumors in children and adolescents. Today, most patients can be cured …
Insulin-like growth factor (IGF) pathway targeting in cancer: role of the IGF axis and opportunities for future combination studies
A Simpson, W Petnga, VM Macaulay… - Targeted …, 2017 - Springer
Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …
cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been …
Role of IGF1R in breast cancer subtypes, stemness, and lineage differentiation
Insulin-like growth factor (IGF) signaling is fundamental for growth and survival. A large body
of evidence (laboratory, epidemiological, and clinical) implicates the exploitation of this …
of evidence (laboratory, epidemiological, and clinical) implicates the exploitation of this …
A review of soft-tissue sarcomas: translation of biological advances into treatment measures
NT Hoang, LA Acevedo, MJ Mann… - Cancer management and …, 2018 - Taylor & Francis
Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an
overall incidence of about five per 100,000 per year. While this diverse family of …
overall incidence of about five per 100,000 per year. While this diverse family of …