Favipiravir as a potential countermeasure against neglected and emerging RNA viruses
Favipiravir, also known as T-705, is an antiviral drug that has been approved in 2014 in
Japan to treat pandemic influenza virus infections. The drug is converted intracellularly into …
Japan to treat pandemic influenza virus infections. The drug is converted intracellularly into …
Influenza virus polymerase inhibitors in clinical development
FG Hayden, N Shindo - Current opinion in infectious diseases, 2019 - journals.lww.com
Influenza virus polymerase inhibitors in clinical developmen... : Current Opinion in Infectious
Diseases Influenza virus polymerase inhibitors in clinical development : Current Opinion in …
Diseases Influenza virus polymerase inhibitors in clinical development : Current Opinion in …
The mechanism of resistance to favipiravir in influenza
Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza
virus infections. While emergence of resistance has been observed for many antiinfluenza …
virus infections. While emergence of resistance has been observed for many antiinfluenza …
Favipiravir in therapy of viral infections
R Łagocka, V Dziedziejko, P Kłos, A Pawlik - Journal of clinical medicine, 2021 - mdpi.com
Favipiravir (FPV) is a novel antiviral drug acting as a competitive inhibitor of RNA-dependent
RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved …
RNA polymerase (RdRp), preventing viral transcription and replication. FPV was approved …
Development and effects of influenza antiviral drugs
H Yin, N Jiang, W Shi, X Chi, S Liu, JL Chen, S Wang - Molecules, 2021 - mdpi.com
Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal
outbreaks each year and unpredictable pandemics occasionally with high morbidity and …
outbreaks each year and unpredictable pandemics occasionally with high morbidity and …
Develo** an appropriate evolutionary baseline model for the study of SARS-CoV-2 patient samples
Over the past 3 years, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
has spread through human populations in several waves, resulting in a global health crisis …
has spread through human populations in several waves, resulting in a global health crisis …
Oral favipiravir exposure and pharmacodynamic effects in adult outpatients with acute influenza
FG Hayden, RP Lenk, C Epstein… - The Journal of Infectious …, 2024 - academic.oup.com
Background The pharmacokinetics of oral favipiravir and the relationships of plasma
concentrations to antiviral effects are incompletely studied in influenza. Methods Serial …
concentrations to antiviral effects are incompletely studied in influenza. Methods Serial …
Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance against a broadly neutralizing hemagglutinin stem antibody
KL Prachanronarong, AS Canale, P Liu… - Journal of …, 2019 - Am Soc Microbiol
Influenza A virus (IAV), a major cause of human morbidity and mortality, continuously
evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies …
evolves in response to selective pressures. Stem-directed, broadly neutralizing antibodies …
[HTML][HTML] Considering mutational meltdown as a potential SARS-CoV-2 treatment strategy
With the rapid global spread of SARS-CoV-2, tremendous efforts have been focused upon
potential treatment strategies (Li and De Clercq 2020). Evolutionary theory has an important …
potential treatment strategies (Li and De Clercq 2020). Evolutionary theory has an important …
Develo** an appropriate evolutionary baseline model for the study of human cytomegalovirus
Human cytomegalovirus (HCMV) represents a major threat to human health, contributing to
both birth defects in neonates as well as organ transplant failure and opportunistic infections …
both birth defects in neonates as well as organ transplant failure and opportunistic infections …