Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Low-coverage whole-genome sequencing followed by imputation has been proposed as a
cost-effective genoty** approach for disease and population genetics studies. However …

Disease-resistance (R) gene cloning in wheat (Triticum aestivum) has been accelerated by
the recent surge of genomic resources, facilitated by advances in sequencing technologies …

Although ancient DNA data have become increasingly more important in studies about past
populations, it is often not feasible or practical to obtain high coverage genomes from poorly …

Low-pass sequencing (sequencing a genome to an average depth less than 1× coverage)
combined with genotype imputation has been proposed as an alternative to genoty** …

Background Inherited susceptibility to common, complex diseases may be caused by rare,
pathogenic variants (“monogenic”) or by the cumulative effect of numerous common variants …

Twelve years have passed since the early outlooks of applying genomic selection (GS) to
forest tree breeding, initially based on deterministic simulations, soon followed by empirical …

Background Uncovering the genetic architecture of economic traits in pigs is important for
agricultural breeding. However, high-density haplotype reference panels are unavailable in …

Most genome-wide association studies are based on samples of European descent. We
assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor …