Accumulating evidence indicates that asymptomatic hyperuricemia is involved in the
development of hypertension and chronic kidney disease. A 2-hit model has been proposed …

Background. Delayed graft function is a frequent complication of kidney transplantation that
requires dialysis in the first week posttransplant. Materials and Methods. We searched for …

Extracellular vesicles (EVs) are known immune-modulators exerting a critical role in kidney
transplantation (KT). EV bioactive cargo includes graft antigens, costimulatory/inhibitory …

The current immunosuppressive protocols used in transplant recipients have improved short-
term outcomes, but long-term allograft failure remains an important clinical problem. Greater …

Over the last decades, our understanding of adaptive immune responses to solid organ
transplantation increased considerably and allowed development of immunosuppressive …

Background Ischemia–reperfusion injury (IRI) upon transplantation is one of the most
impactful events that the kidney graft suffers during its life. Its clinical manifestation in the …

The widening gap between organ availability and need is resulting in a worldwide crisis,
particularly concerning kidney transplantation. Regenerative medicine options are …

Organ transplantation is the main treatment for end-stage organ failure, which has rescued
tens of thousands of lives. Immune rejection is the main factor affecting the survival of …

Acute rejection of human allografts has been viewed mostly through the lens of adaptive
immunity, and the intragraft landscape of innate immunity genes has not been characterized …

The advances in transplant immunosuppression have reduced substantially the incidence of
kidney graft rejection. In recent years, the focus has moved from preventing rejection to …