For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …

Although vertebrate DNA is generally depleted in the dinucleotide CpG, it has recently been
shown that some vertebrate genes contain CpG islands, regions of DNA with a high G+ C …

Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression
of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T …

Vascular endothelial growth factor (VEGF) is an apparently endothelial cell-specific mitogen
that is structurally related to platelet-derived growth factor. By Northern blot and protein …

Mitochondrial transcription factor A (mtTFA), the product of a nuclear gene, stimulates
transcription from the two divergent mitochondrial promoters and is likely the principal …

Expression of the interferon-β (IFN-β) gene is induced by a variety of agents, including
viruses. Evidence has been provided that a mouse nuclear factor, termed interferon …

The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile
acids across the hepatocyte canalicular membrane and for generation of bile acid …