Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain
a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high …

Extensive research within the last several decades has revealed that the major risk factors
for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental …

Background Chronic diseases are a major cause of mortality worldwide, and despite the
recent development in treatment modalities, synthetic drugs have continued to show toxic …

Abstract Alzheimer's disease (AD), the most common form of dementia, has tremendous
social and economic impact worldwide. Research has shown an association between …

Diosgenin (DG), a well‐known steroidal sapogenin, is present abundantly in medicinal
herbs such as Dioscorea rhizome, Dioscorea villosa, Trigonella foenum-graecum, Smilax …

Diosgenin (Di), a steroidal sapogenin derived from plants, has been shown to exert
anticancer effects in preclinical studies. Using Di as a starting material, various Di …

Neurodegenerative diseases (NDs) are one of major public health problems and their
impact is continuously growing. Curcumin has been proposed for the treatment of several of …

There is a continuing, urgent need for an ophthalmic (eye) drop for the clinical therapy of
age-related macular degeneration (AMD), a leading cause of blindness. Here, we report the …

A series of methotrexate-diosgenin conjugates was designed and synthesized to enhance
the passive internalization of methotrexate (MTX) into transport-resistant cells. The inhibitory …

Diosgenin, a steroidal saponin, is a natural product found in many plants. Diosgenin has a
wide range of pharmacological activities, and has been used to treat cancer, nervous system …