Heart disease and stroke statistics—2022 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, A Alonso… - Circulation, 2022 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Heart disease and stroke statistics—2023 update: a report from the American Heart Association

CW Tsao, AW Aday, ZI Almarzooq, CAM Anderson… - Circulation, 2023 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

The GTEx Consortium atlas of genetic regulatory effects across human tissues

GTEx Consortium - Science, 2020 - science.org
The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

Identification of common genetic risk variants for autism spectrum disorder

J Grove, S Ripke, TD Als, M Mattheisen, RK Walters… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

The MR-Base platform supports systematic causal inference across the human phenome

G Hemani, J Zheng, B Elsworth, KH Wade… - elife, 2018 - elifesciences.org
Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Heart disease and stroke statistics—2020 update: a report from the American Heart Association

SS Virani, A Alonso, EJ Benjamin, MS Bittencourt… - Circulation, 2020 - Am Heart Assoc
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …

Heart disease and stroke statistics—2021 update: a report from the American Heart Association

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - Circulation, 2021 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

PH Lee, V Anttila, H Won, YCA Feng, J Rosenthal… - Cell, 2019 - cell.com
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …

Genetics of circadian rhythms and sleep in human health and disease

JM Lane, J Qian, E Mignot, S Redline… - Nature Reviews …, 2023 - nature.com
Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …