Role of GABAA receptors in alcohol use disorders suggested by chronic intermittent ethanol (CIE) rodent model

RW Olsen, J Liang - Molecular brain, 2017 - Springer
GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on
the brain and behavior. One-dose ethanol exposure induces transient plastic changes in …

Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology

D Castellano, RD Shepard, W Lu - Frontiers in neuroscience, 2021 - frontiersin.org
Diverse populations of GABAA receptors (GABAARs) throughout the brain mediate fast
inhibitory transmission and are modulated by various endogenous ligands and therapeutic …

GABAA receptor α4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol

D Chandra, F Jia, J Liang, Z Peng… - Proceedings of the …, 2006 - pnas.org
The neurotransmitter GABA mediates the majority of rapid inhibition in the CNS. Inhibition
can occur via the conventional mechanism, the transient activation of subsynaptic GABAA …

Withdrawal from 3α-OH-5α-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the …

SS Smith, QH Gong, X Li, MH Moran, D Bitran… - Journal of …, 1998 - jneurosci.org
In the present study, we have characterized properties of steroid withdrawal using a
pseudopregnant rat model. This paradigm results in increased production of endogenous …

Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes

SG Brickley, SG Cull-Candy, M Farrant - Journal of Neuroscience, 1999 - jneurosci.org
Many neurons express a multiplicity of GABAA receptor subunit isoforms. Despite having
only a single source of inhibitory input, the cerebellar granule cell displays, at various stages …

Region-specific developmental specialization of GABA–glycine cosynapses in laminas I–II of the rat spinal dorsal horn

AF Keller, JAM Coull, N Chery, P Poisbeau… - Journal of …, 2001 - jneurosci.org
The spinal dorsal horn is the first level of the CNS in which nociceptive input from sensory
afferents is integrated and transmitted. Although inhibitory control in this region has a crucial …

Modulation of synaptic GABAA receptor function by PKA and PKC in adult hippocampal neurons

P Poisbeau, MC Cheney, MD Browning… - Journal of …, 1999 - jneurosci.org
Several protein kinases are known to phosphorylate Ser/Thr residues of certain GABAA
receptor subunits. Yet, the effect of phosphorylation on GABAA receptor function in neurons …

Effect of zolpidem on miniature IPSCs and occupancy of postsynaptic GABAA receptors in central synapses

D Perrais, N Ropert - Journal of Neuroscience, 1999 - jneurosci.org
GABAA-mediated miniature IPSCs (mIPSCs) were recorded from layer V pyramidal neurons
of the visual cortex using whole-cell patch-clamp recording in rat brain slices. At room …

Cell surface stability of γ-aminobutyric acid type A receptors: Dependence on protein kinase C activity and subunit composition

CN Connolly, JT Kittler, P Thomas, JM Uren… - Journal of Biological …, 1999 - jbc.org
Type A γ-aminobutyric acid receptors (GABA A), the major sites of fast synaptic inhibition in
the brain, are believed to be composed predominantly of α, β, and γ subunits. Although cell …

[BUCH][B] Diversity in the neuronal machine: order and variability in interneuronal microcircuits

I Soltesz - 2006 - books.google.com
This book is a colorful journey into the fascinatingly diverse world of interneurons, an
important class of highly heterogeneous cells found in all cortical neuronal networks …