Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …

Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers
between the external environment and the internal milieu. To cross these epithelial barriers …

The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a
multifunctional single transmembrane glycoprotein. Recent studies have advanced our …

β-Site amyloid precursor protein-cleaving enzyme (BACE1) is a membrane-tethered
member of the aspartyl proteases that has been identified as β-secretase. BACE1 is targeted …

The voltage-gated sodium channel is critical for cardiomyocyte function and consists of a
protein complex comprising a pore-forming α subunit and two associated β subunits. It has …

Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo
sorting from endosomal compartments. In concert with its accessory proteins, the retromer …

Background Information Cardiac channelopathies arise by mutations in genes encoding ion
channel subunits. One example is Brugada Syndrome (BrS), which causes arrhythmias and …

The retromer complex is a highly conserved membrane trafficking assembly composed of
three proteins-Vps26, Vps29 and Vps35-that were identified over a decade ago in …

The voltage-gated sodium (Na V) channel is critical for cardiomyocyte function since it is
responsible for action potential initiation and its propagation throughout the cell. It consists of …

Retromer is an evolutionary conserved protein complex required for endosome-to-Golgi
retrieval of receptors for lysosomal hydrolases. It is constituted by a heterotrimer encoded by …