Lipids represent the essential components of membranes, serve as fuels for high-energy
processes, and play crucial roles in signaling and cellular function. One of the key hallmarks …

Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …

Kidney diseases are major health problem and understanding the underlined mechanisms
that lead to kidney diseases are critical research points with a marked potential impact on …

Chronic ulceration of the colon is associated with the activation of TLR4/NF-κB and
P2X7R/NLRP3 signaling pathways. We investigated the effect of individual or combined …

Carbohydrates and lipids are two components of the diet that provide the necessary energy
to carry out various physiological processes to help maintain homeostasis in the body …

Aim Metformin and empagliflozin combined therapy may have complementary effects that go
beyond the well-recognized targets of their monotherapy through AMPK activation …

Diabetic nonhealing ulcers are the leading cause of nontraumatic amputations. An
increased cancer risk has been found in patients treated with current therapies such as …

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide.
Telmisartan (TLM), a BSC class II drug, has been reported to have antiproliferative activity in …

Mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-ĸB signaling have been
recognized for their causal connection with liver fibrosis. Hence, it is encouraging to discover …

Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It
was suggested that albendazole (ABZ) is a powerful inhibitor of several carcinoma types …