Small‐molecule prodrug nanoassemblies: an emerging nanoplatform for anticancer drug delivery

G Li, B Sun, Y Li, C Luo, Z He, J Sun - Small, 2021 - Wiley Online Library
The antitumor efficiency and clinical translation of traditional nanomedicines is mainly
restricted by low drug loading, complex preparation technology, and potential toxicity …

Lipid–drug conjugate for enhancing drug delivery

D Irby, C Du, F Li - Molecular pharmaceutics, 2017 - ACS Publications
Lipid–drug conjugates (LDCs) are drug molecules that have been covalently modified with
lipids. The conjugation of lipids to drug molecules increases lipophilicity and also changes …

Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents

A Angelova, VM Garamus, B Angelov, Z Tian… - Advances in colloid and …, 2017 - Elsevier
The present work highlights recent achievements in development of nanostructured
dispersions and biocolloids for drug delivery applications. We emphasize the key role of …

Nanotechnology in colorectal cancer for precision diagnosis and therapy

B Brar, K Ranjan, A Palria, R Kumar… - Frontiers in …, 2021 - frontiersin.org
Colorectal cancer (CRC) is the third most frequently occurring tumor in the human
population. CRCs are usually adenocarcinomatous and originate as a polyp on the inner …

Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum cap**

B Kumar, S Kulanthaivel, A Mondal, S Mishra… - Colloids and Surfaces B …, 2017 - Elsevier
In the global context of increasing colonic diseases, colon specific oral drug delivery
systems have shown promise as an effective therapeutic modality. Herein, we developed a …

Engineered nanoparticles for imaging and drug delivery in colorectal cancer

E Pavitra, B Dariya, G Srivani, SM Kang, A Alam… - Seminars in cancer …, 2021 - Elsevier
Colorectal cancer (CRC) is one of the deadliest diseases worldwide due to a lack of early
detection methods and appropriate drug delivery strategies. Conventional imaging …

Integrating cutting-edge technologies: AI, IoT, blockchain and nanotechnology for enhanced diagnosis and treatment of colorectal cancer-A review

P Pandurangan, AD Rakshi, MSA Sundar… - Journal of Drug Delivery …, 2024 - Elsevier
Currently adopted methods that are used for diagnosis and treatment are not effective in the
successful management of CRC. Nanotechnology has explored a new beginning to the …

Penetrable nanoplatform for “cold” tumor immune microenvironment reeducation

Q Chen, Y He, Y Wang, C Li, Y Zhang, Q Guo… - Advanced …, 2020 - Wiley Online Library
Lack of tumor‐infiltration lymphocytes (TILs) and resistances by overexpressed
immunosuppressive cells (principally, myeloid‐derived suppressor cells (MDSCs)) in tumor …

Self-assembled lipid–prodrug nanoparticles

P Couvreur, S Lepetre-Mouelhi, E Garbayo… - Nature Reviews …, 2023 - nature.com
Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery

D Sobot, S Mura, SO Yesylevskyy, L Dalbin… - Nature …, 2017 - nature.com
Once introduced in the organism, the interaction of nanoparticles with various biomolecules
strongly impacts their fate. Here we show that nanoparticles made of the squalene derivative …