Parkinson's disease: from pathogenesis to pharmacogenomics
R Cacabelos - International journal of molecular sciences, 2017 - mdpi.com
Parkinson's disease (PD) is the second most important age-related neurodegenerative
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from …
The genetics of Parkinson's disease and implications for clinical practice
JO Day, S Mullin - Genes, 2021 - mdpi.com
The genetic landscape of Parkinson's disease (PD) is characterised by rare high penetrance
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a …
New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty …
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Insomnia is the second most prevalent mental disorder, with no sufficient treatment
available. Despite substantial heritability, insight into the associated genes and …
available. Despite substantial heritability, insight into the associated genes and …
Mitochondrial dysfunction and oxidative stress in Parkinson's disease
SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
Genetics in Parkinson disease: Mendelian versus non‐Mendelian inheritance
DG Hernandez, X Reed… - Journal of …, 2016 - Wiley Online Library
Parkinson's disease is a common, progressive neurodegenerative disorder, affecting 3% of
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …
those older than 75 years of age. Clinically, Parkinson's disease (PD) is associated with …
Parkinson's disease: genetics and pathogenesis
Recent investigation into the mechanisms of Parkinson's disease (PD) has generated
remarkable insight while simultaneously challenging traditional conceptual frameworks …
remarkable insight while simultaneously challenging traditional conceptual frameworks …
[HTML][HTML] Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
International Parkinson Disease Genomics Consortium - The Lancet, 2011 - Elsevier
BACKGROUND: Genome-wide association studies (GWAS) for Parkinson's disease have
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …
linked two loci (MAPT and SNCA) to risk of Parkinson's disease. We aimed to identify novel …
Missing pieces in the Parkinson's disease puzzle
JA Obeso, MC Rodriguez-Oroz, CG Goetz, C Marin… - Nature medicine, 2010 - nature.com
Parkinson's disease is a neurodegenerative process characterized by numerous motor and
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …
nonmotor clinical manifestations for which effective, mechanism-based treatments remain …