Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …

One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …

BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

GABAergic inhibitory circuits play an essential role in coordinating various hippocampal
functions. Several decades of work dedicated to a thorough characterization of hippocampal …

Fast-spiking parvalbumin (PV) interneurons are inhibitory interneurons with unique
morphological and functional properties that allow them to precisely control local circuitry …

One leading hypothesis suggests that memories are stored in ensembles of neurons (or
'engram cells') and that successful recall involves reactivation of these ensembles. A logical …

The generation of myelin-forming oligodendrocytes persists throughout life and is regulated
by neural activity. Here we tested whether experience-driven changes in …

Experience-dependent myelination is hypothesized to shape neural circuit function and
subsequent behavioral output. Using a contextual fear memory task in mice, we demonstrate …

How do passing moments turn into lasting memories? Sheltered from external tasks and
distractions, sleep constitutes an optimal state for the brain to reprocess and consolidate …

What happens to memories as days, weeks and years go by has long been a fundamental
question in neuroscience and psychology. For decades, researchers have attempted to …