Three-dimensional in vitro culture models in oncology research
Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …
Air− liquid Interface cultures of the healthy and diseased human respiratory tract: promises, challenges, and future directions
D Baldassi, B Gabold, OM Merkel - Advanced nanobiomed …, 2021 - Wiley Online Library
Air− liquid interface (ALI) culture models currently represent a valid instrument to recreate
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
the typical aspects of the respiratory tract in vitro in both healthy and diseased state. They …
In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective
When assessing the risk and hazard of a non-pharmaceutical compound, the first step is
determining acute toxicity, including toxicity following inhalation. Inhalation is a major …
determining acute toxicity, including toxicity following inhalation. Inhalation is a major …
Review of the mechanism of nanocarriers and technological developments in the field of nanoparticles for applications in cancer theragnostics
Cancer cannot be controlled by the usage of drugs alone, and thus, nanotechnology is an
important technique that can provide the drug with an impetus to act more effectively. There …
important technique that can provide the drug with an impetus to act more effectively. There …
Modifying and Integrating in vitro and ex vivo Respiratory Models for Inhalation Drug Screening
For the past 50 years, the route of inhalation has been utilized to administer therapies to
treat a variety of respiratory and pulmonary diseases. When compared with other drug …
treat a variety of respiratory and pulmonary diseases. When compared with other drug …
Emerging trends in the methodology of environmental toxicology: 3D cell culture and its applications
Human diseases and health concerns caused by environmental pollutants are globally
emerging. Therefore, rapid and efficient evaluation of the effects of environmental pollutants …
emerging. Therefore, rapid and efficient evaluation of the effects of environmental pollutants …
Development of lung tissue models and their applications
N Petpiroon, W Netkueakul, K Sukrak, C Wang, Y Liang… - Life Sciences, 2023 - Elsevier
The lungs are important organs that play a critical role in the development of specific
diseases, as well as responding to the effects of drugs, chemicals, and environmental …
diseases, as well as responding to the effects of drugs, chemicals, and environmental …
[HTML][HTML] The role of extracellular vesicles in non-small-cell lung cancer, the unknowns, and how new approach methodologies can support new knowledge generation …
Extracellular vesicles (EVs) are nanosized particles released from most human cell types
that contain a variety of cargos responsible for mediating cell-to-cell and organ-to-organ …
that contain a variety of cargos responsible for mediating cell-to-cell and organ-to-organ …
Preclinical development of orally inhaled drugs (OIDs)—are animal models predictive or shall we move towards in vitro non-animal models?
Simple Summary This commentary focuses on the methods currently available to test the
efficacy and safety of new orally inhaled drugs for the treatment of uncurable respiratory …
efficacy and safety of new orally inhaled drugs for the treatment of uncurable respiratory …
Non-coding RNAs in lung tumor initiation and progression
RM Santos, C Moreno, WC Zhang - International Journal of Molecular …, 2020 - mdpi.com
Lung cancer is one of the deadliest forms of cancer affecting society today. Non-coding
RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs …
RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs …