Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for
regenerative therapy, disease modeling, and drug discovery. iPSCs allow for the production …

Cardiovascular disease remains the leading cause of morbidity and mortality in the
developed world. In recent decades, extraordinary effort has been devoted to defining the …

We have previously developed a high-throughput bioengineered human cardiac organoid
(hCO) platform, which provides functional contractile tissue with biological properties similar …

Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are
associated with cardiovascular side effects ranging from induced arrhythmias to heart …

Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human
physiology and disease at the cellular level. They also have the potential to be leveraged in …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

Background: Left ventricular noncompaction cardiomyopathy (LVNC) was discovered half a
century ago as a cardiomyopathy with excessive trabeculation and a thin ventricular wall. In …

Background: Electronic cigarettes (e-cigarettes) have experienced a tremendous increase in
use. Unlike cigarette smoking, the effects of e-cigarettes and their constituents on mediating …

Abstract Lamin A/C (LMNA) is one of the most frequently mutated genes associated with
dilated cardiomyopathy (DCM). DCM related to mutations in LMNA is a common inherited …

Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …