Cancers are not composed merely of cancer cells alone; instead, they are complex
'ecosystems' comprising many different cell types and noncellular factors. The tumour stroma …

Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment
of a range of diseases or medical conditions. Autologous or allogeneic MSCs obtained from …

Tumour progression is dependent on the interaction between tumour cells and cells of the
surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell …

The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

The interaction between tumor cells and non-malignant hosts cells within the tumor
microenvironment (TME) is critical to the pathophysiology of cancer. These non-malignant …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Stromal fibroblasts become altered in response to solid cancers, to exhibit myofibroblastic
characteristics, with disease promoting influence. Infiltrating mesenchymal stem cells (MSC) …

Emerging evidence suggests that mesenchymal stem cells (MSCs) are often recruited to
tumor sites but their functional significance in tumor growth and disease progression …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

The interactions between tumor cells and the non-malignant stromal and immune cells that
make up the tumor microenvironment (TME) are critical to the pathophysiology of cancer …