Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

SARS-CoV-2 biology and host interactions

S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

F Kabinger, C Stiller, J Schmitzová… - Nature structural & …, 2021 - nature.com
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the
treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA …

[HTML][HTML] Recent advances in electrochemical biosensors–A brief review

MS Sumitha, TS Xavier - Hybrid Advances, 2023 - Elsevier
A sensitive biological system and a detector system with appropriate transducers for
obtaining the output signals make up a biosensor. These devices have a wide range of …

Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template

CJ Gordon, EP Tchesnokov, RF Schinazi… - Journal of Biological …, 2021 - jbc.org
The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus
2 is an important target in current drug development efforts for the treatment of coronavirus …

Emerging SARS-CoV-2 variants and impact in global vaccination programs against SARS-CoV-2/COVID-19

CE Gómez, B Perdiguero, M Esteban - Vaccines, 2021 - mdpi.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
in different continents is causing a major concern in human global health. These variants …

COVID-19: characteristics and therapeutics

R Chilamakuri, S Agarwal - Cells, 2021 - mdpi.com
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2

NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - journals.asm.org
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

Antiviral drug discovery: preparing for the next pandemic

CS Adamson, K Chibale, RJM Goss… - Chemical Society …, 2021 - pubs.rsc.org
Clinically approved antiviral drugs are currently available for only 10 of the more than 220
viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need …