B cell receptor (BCR) signalling is crucial for normal B cell development and adaptive
immunity. BCR signalling also supports the survival and growth of malignant B cells in …

Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

Hematological malignancies (HM) are a collection of malignant transformations originating
from cells in the primary or secondary lymphoid organs. Leukemia, lymphoma, and multiple …

Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …

Despite progress in exploiting therapeutically the genetic vulnerabilities of leukemia and
lymphoma, the outcome is often extended progression-free survival but not tumor …

To identify new therapeutic targets in acute myeloid leukemia (AML), we performed small-
molecule and small-interfering RNA (siRNA) screens of primary AML patient samples. In …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …

Macrophages, the major component of the mononuclear phagocyte system, uptake and
clear systemically administered nanoparticles (NPs). Therefore, leveraging macrophages as …

Microenvironment contributes to follicular lymphoma (FL) pathogenesis and impacts survival
with macrophages playing a controversial role. In the present study, using FL primary …