Immune responses differ between men and women, with women at higher risk of develo**
chronic autoimmune diseases and having more robust immune responses to many viruses …

The human organism comprises various physiological and organ systems, each with its own
structural organization and functional complexity, leading to complex, transient, fluctuating …

Circadian, metabolic, and reproductive systems are inter-regulated. Excessive fatness and
circadian disruption alter normal physiology and the endocrine milieu, including cortisol, the …

Rhythmic hormonal secretion is key for sustaining health. While a central pacemaker in the
hypothalamus is the main driver of circadian periodicity, many hormones oscillate with …

Chronic stress is suspected to be a causal factor of female subfertility; however, the
underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the …

Blast-induced traumatic brain injury (bTBI) frequently results in sleep-wake disturbances.
However, limited studies have investigated the molecular signaling mechanisms underlying …

Zishen Yutai Pills (ZYP) is a safe and well quality-controlled TCM preparation with promising
effects in many fields of reproduction, including prevention of miscarriage, increase of …

Introduction The impact of stress on reproductive function is significant. Hypothalamic
paraventricular nucleus (PVN) corticotrophin-releasing hormone (CRH) plays a major role in …

A new mathematical model for biological rhythms in the hypothalamic–pituitary–adrenal
(HPA) axis is proposed. This model takes the form of a system of impulsive time-delay …

Psychosocial stress disrupts reproduction and interferes with pulsatile LH secretion. The
posterodorsal medial amygdala (MePD) is an upstream modulator of the reproductive axis …